If you prefer natural fibers, you can get merino wool cycling socks instead, which offer similar moisture management performance, plus are naturally resistant to odor buildup. So serious cycling socks are made out of synthetic materials like nylon or polyester, both of which wick moisture and dry quickly. Sweaty feet, in addition to being generally uncomfortable, are more blister-prone. Whether you want compression bands in your socks, though, is less a matter of any noticeable performance advantage and more a matter of whether you like the feel of socks that are built that way. ![]() Some cycling socks even have compression bands (around the arches), which are designed to provide a more supportive fit. For this reason, the socks that go into the cycling shoes need to be snug as well. ![]() In addition, cycling shoes are designed to fit snugly so that no energy is dissipated through the movement of your foot inside your shoes.
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Just expect that to come to pass in New York. He hasn’t gotten paid big by NBA standards and he’s not letting this opportunity pass. Hart was on a minimum-level contract his first three years in the league and only in the past two years has his salary jumped up slightly above league-average money. That was not very subtle code that he wants to stay with the Knicks but there will be no discount. So, I’ve also got to take that into account, too.” Coming up, this contract is hopefully my biggest one, one where I’m making sure my family’s fully taken care of. I would love for it to be New York and hopefully the organization feels the same way. “Just find a home somewhere where we are valued and really like living there. “I want bigger things for my wife and myself,” Hart said. ![]() Here is what he told Marc Spears of ESPN’s Andscape a few months ago. Hart also sounds like a guy who wants to stay in New York. There may be no more Thibodeau player on the Knicks roster than Hart you know where the coach’s loyalties lie. ![]() The CAA-repped swingman’s eventual deal to re-sign with the Knicks and a front office helmed by CAA alumnus Leon Rose is more often referred to be rivals as inevitable. I have yet to encounter a single team that believes Hart will be gettable. But then reality hits them, reports Marc Stein in his newsletter. That has other teams drooling at the chance to snap him up, right? Yes. He has a $12.9 million player option, but he will make more than that on the market - $17-18 million a year to start? - and grab the security of a multi-year contract. Hart is expected to be a free agent this summer. Especially the way he has helped lift up these Knicks in the postseason. In theory Brooklyn could trade him, but they would have to add so many sweeteners it wouldn’t be worth it.īut before Simmons returns to the court in Brooklyn, will we see him in the Philippines?Įvery GM in the NBA watches the scrappy, versatile, two-way game of Josh Hart and sees a player that can help their team. While Nets fans - and probably the front office - would like to trade him, that is next to impossible because Simmons has two fully guaranteed years and $78 million remaining on his contract. Simmons will be back with the Nets in the fall. He played in 42 games, averaging 6.9 points and 6.3 rebounds a game, but his unwillingness to shoot outside the paint - 94.5% of his shots came in the paint this season - had coach Jacque Vaughn using him in a limited role, often as a backup center. Simmons was in and out of the Nets lineup this past season with knee and back issues ( his season ended because of a nerve impingement in his back). Simmons has yet to suit up for his native Australia in an Olympics or World Cup. “I love what coach Goorjian is building with the Boomers and I look forward to being a part of the program in the future.” “I’m currently rehabilitating my back injury and putting my full effort and focus towards that,” Simmons said. Here is how Simmons responded, via Perth Now. “There were unfortunate circumstances, but I feel like he is going to make himself available.” “I think his mindset is getting healthy, getting in shape and getting ready to play in this ,” Goorjian said. He has Simmons in the selection pool the Boomer can take with them to the World Cup and said this to SEN Radio in Sydney, reports Brian Windhorst of ESPN. All rights reserved.Is the next place we see Ben Simmons on a basketball court in the Philippines during the World Cup this September?Īustralia coach Brian Goorjian hopes so. Terms of Use and Privacy Policy and Safety Information / Your California Privacy Rights are applicable to you. ^ Back to Top ^ © 2023 ESPN Internet Ventures. You have reached a degraded version of because you're using an unsupported version of Internet Explorer.įor a complete experience, please upgrade or use a supported browser ![]() She said she moved to Mount Airy after her longtime home in Los Angeles was twice burglarized. ![]() Lynn also had recurring roles on Family Affair and My Three Sons and showed up on episodes of The Farmer’s Daughter, Mod Squad, Little House on the Prairie, Police Story and Barnaby Jones. She played Ray Bolger’s sister-in-law in 1953-54 on the ABC show Where’s Raymond?, had small parts in such films as Gun for a Coward (1956) and Meet Me in Las Vegas (1956) and guest-starred on series including Wagon Train, Lawman and Tales of Wells Fargo before her gig on Texas John Slaughter. I didn’t understand that they were having great difficulty because people were staying home instead of going to the movies. “When they asked me what I had been doing, I said, ‘I’ve been doing live television, it’s absolutely wonderful, it’s like doing a play!’ They’d all just freeze. “The studios hated television,” she noted. She then played the youngster sister of Barbara Bates’ character in June Bride, starring Bette Davis and Robert Montgomery, and the daughters of Loretta Young in Mother Is a Freshman (1949) and Fred MacMurray and O’Hara in Father Was a Fullback (1949).Īfter working again with Webb in Cheaper by the Dozen and with Davis in Payment on Demand (1951), Lynn returned to New York and performed frequently on live TV, which she said derailed her movie career. She came to Los Angeles with her mom and made her big-screen bow in the family comedy Sitting Pretty (1948), starring Robert Young, Maureen O’Hara and Clifton Webb. Though the couple has passed on, they have left behind them their daughter Dixie, and son, Andy Griffith Junior, to help keep their story alive.After eight months with the USO, she appeared in the Broadway-bound comedy Park Avenue, where she was spotted by a Fox talent scout and signed by the studio. YOU MAY ALSO LIKE: 5 Things You Didn't Know About Hollywood's Lovable Goofball, Jim Nabors Andy passed away at the age of 80 in 2012. Barbara Griffith passed away at the age of 53 in 1980. After 23 years of being married, they were suddenly apart in the year 1972. (later known by his middle name, Samuel), died in 1996 after a long battle with alcoholism. The couple adopted two children: a boy, Andy Griffith, Jr., and a daughter, Dixie Griffith. His married his first wife, Barbara Bray Edwards, in 1949. Sadly, where love had once blossomed between the two, they would later find themselves separated and divorced. Andy Griffith was married three times in his life. The hit comedy series went on for eight seasons over the course of eight years. WATCH: Cameo By Andy Griffith’s Wife Barbara Edwards She also spends some time in the episode singing. Masters," she says to the choir director. Her presence was nothing but a cameo, but she did appear as part of the Mayberry choir for an episode in the fourth season. RELATED: Classic Episode Of The Andy Griffith Show On How To Not Raise A Spoiled Kid Still Rings True TodayĪndy Griffith’s wife even surprised some, those who noticed, by making an appearance in her husband's hit show. Ten years before The Andy Griffith Show came into being, Barabara and Andy traveled across North Carolina performing in different places. What started off as an interest in a beautiful woman who could sing became so much more. He graduated in 1949, and that same year, Barbara became Andy Griffith’s wife. "My dad was quite taken by my mom's operatic soprano voice," she shared.Īndy ventured off to college to become a preacher, but had a change in heart and pursued music instead. Andy heard her vocals and immediately took a fancy to the young lady. Her parents first met at Carolina Playmakers Repertory Theater at the University of North Carolina-Chapel Hill. RELATED: Andy Griffith And Don Knotts Singing ‘Church In The Wildwood' Is A Throwback To Simpler Times There's some candid history between the lovers, which their daughter Dixie took some time to reveal. Most of us know Andy Griffith or have heard of his stardom on the hit show The Andy Griffith Show. ![]() When you do, the dark gray DOWNLOAD button will turn red. Please click in that checkbox to agree to the terms. When you do, a dark gray DOWNLOAD button will appear below that, a checkbox will be shown asking you to agree to the terms of the disclaimer to continue with the download. Next, below the red box labeled "DRIVERS", locate the CUPS file, then click the SELECT button to the right of the filename. Please note that you may need to scroll up or down in the list to select your operating system.Ģ. Verify that the operating system detected in the "OPERATING SYSTEM" field is correct, and if it is not, please click the drop-down menu to select your operating system. ![]() Once on the initial download page for your model, please do the following:ġ. Please click here to go to the PIXMA MG8120 Drivers and Downloads page. Next, we will want to download the latest drivers from the Canon USA website. If your printer is still listed on the left select your printer and then click the minus (-) button to delete it. After you reset the printing system, the list of printers in Printers & Scanners preferences should be empty. Hold down the Control key as you click in the list at the left, then choose “Reset printing system” from the menu that appears. ![]() Choose Apple menu > System Preferences, then click Printers & Scanners.Ģ. To reset the printing system, please follow these steps:ġ. I would like to have you reset the printing system on your Mac, then reinstall the drivers and software to see if this will resolve the issue. ![]() One History question asked what the 19th Amendment to the U.S. Some questions are quite obscure, but others are very easy. There were plenty of questions asking about real information, too, but it was all mixed together with questions that definitely won't stand the test of time.Īs with most of the other Trivial Pursuit editions, the difficulty of the questions is mixed. ![]() I prefer my trivia to be about real facts and knowledge, not fluff. Again, Entertainment should have been the category. Another example that was in the Geography category barely mentioned France in the question, but the answer related to the movie Beauty and the Beast. I would have thought that would have fallen under Entertainment, but perhaps they consider the Internet to be Science. For example, a question about Twitter and Ashton Kutcher was in Science and Nature. Second, the questions are more modern and up-to-date than those in the editions I'm used to playing, but their organization into categories is sometimes way off. First, there are the usual two boxes of cards, but there aren't enough cards supplied to come close to filling them up. I'm thrilled that they are continuing to put out conventional versions of Trivial Pursuit. Box has 1 minor split corner that has been. Lord of the Rings Trivial Pursuit Game Trilogy DVD Edition Parker Bro $25 Lord of the Rings Trivial Pursuit DVD Game TrilogyLord of the Rings Trivial Pursuit DVD Game TrilogyGood condition. Lord of the Rings Trivial Pursuit Game Trilogy DVD Edition Parker Bro - $25 (Grand Prairie).Hasbro Games Trivial Pursuit 20th Anniversary Edition Factory sealed. Trivial Pursuit 20th Anniversary Edition Sealed Hasbro Games NEW - $20 (Prescott).Board Games (Scene It, Trivial Pursuit, Planet Earth) - $10 (Winchester, VA)īoard Games:Planet Earth DVD GameScene It DVD 80s EditionScene It DVD Harry PotterLord of the Rings DVD Trivial Pursuit $10 each, discount on multiplesCan meet most days in Winchester, Ashburn or Capon Bridge only**.Do you ever wonder who first thought of Trivial Pursuit?Canadian. 1992 Trivial Pursuit-Family Edition 2 Box Card Set-For Use With Any Ma - $15 (Baltimore) ‹ image 1 of 3 › (google map)ġ992 Trivial Pursuit-Family Edition 2 Box Card Set-For Use With Any Master Game $151992 Trivial Pursuit-Family Edition 2 Box Card Set-For Use With Any Master Game.Featuring thousands of questions including many on DVD.This version of Trivial Pursuit features thousands of questions fro. Excellent Condition with all Pieces Present, $5.00.The Trivia Board Game of TV, Movies, Music, Fads and More. Trivial Pursuit Boardgame, DVD Pop Culture Edition. ![]()
The only reported nonhematologic grade ≥3 adverse events that occurred more frequently in the radium-223–treated patient group were anorexia (2% versus 1%) and a decreased appetite (2 patients vs. In general, radium-223 was well tolerated by patients, with grade 3 or 4 adverse events occurring more frequently in the placebo-treated group (62%) than in patients treated with radium-223 (56%). The median overall survival was 65 weeks in the radium-223–treated group, and 46 weeks in the placebo-treated group ( P = 0.056). In a follow-up report, 24 months after the first injection of study medication, no long-term treatment-related toxicity was noted ( 24). Severe nonhematologic adverse events occurred in 3 (9.1%) radium-223–treated patients and in 5 (16.7%) placebo-treated patients. Grades 3 and 4 adverse events occurred in 3 (9.1%) and 0 (0%) radium-223–treated patients and in 1 (3.3%) and 1 (3.3%) placebo-treated patients, respectively. None of the 33 radium-223-treated patients discontinued treatment because of adverse events. Low toxicity of radium-223 was confirmed in this phase II study. The median time to skeletal-related event was 14 weeks in the radium-223–treated group versus 11 weeks in patients treated with placebo ( P = 0.257 ref. Therefore, the half-lives of radon-219 (4.0 seconds), bismuth-211 (2.1 minutes), and thallium-207 (4.8 minutes) seem to be long enough to allow diffusion from the primary accumulation site.Ī subsequent phase II study compared treatment of 50 kBq/kg radium-223 with placebo treatment in 64 CRPC patients with painful bone metastases ( 23, 24). These daughter nuclides do not have a chemical similarity to calcium ions. The half-life of radium-223 is 11.4 days the half-lives of its daughter nuclides range from seconds to minutes. Because of the size and high energy of α-particles, these particles are highly effective in inducing double-strand breaks in DNA within 100 μm. Both α- and β-irradiation can induce local therapy by inducing damage in the surrounding tissue. During the decay of each radium-223 isotope, 4 α-particles and 2 electrons (β-particles) are emitted ( Table 1). Radium-223 is an α-emitting radioisotope that decays via 7 daughter nuclides before it stabilizes as lead-207 ( Fig. ![]() In ionic form, radium accumulates in bones at areas with increased bone turnover because of its chemical similarity to calcium ions both are alkaline earth metals ( 18, 19). Moreover, as surrounding tissue, including the bone marrow, can be damaged as well, significant adverse events such as bone marrow failure may occur in treated patients.Ģ23RaCl 2 is a water-soluble radium salt. However, the duration of response is limited the effect of these treatments on overall survival has not been studied. Such therapies result in symptomatic relief in more than half of patients ( 16, 17). Multiple agents have been approved by the US Food and Drug Administration (FDA) for the palliative treatment of bone metastases in mCRPC patients, such as external beam radiotherapy and the β-emitting radiopharmaceuticals strontium-89 (1.5–2.2 MBq/kg) and samarium-153 (37 MBq/kg Table 1). Hence, specific treatment of bone metastases may significantly lower the burden of prostate cancer disease ( 14, 15). Bone metastases may lead to severe morbidity, such as bone marrow failure, pathological fractures, and spinal cord compression, reducing quality of life and potentially resulting in death ( 12, 13). Prostate cancer primarily metastasizes to the bone ( 11). Further studies are required to optimize its dosing and to confirm its efficacy and safety in cancer patients. 223RaCl 2 is the first bone-targeting antitumor therapy that received FDA approval based on a significant extended median overall survival. The radioisotope was well tolerated and gave limited bone marrow suppression. At a prespecified interim analysis, the primary endpoint of median overall survival was significantly extended by 3.6 months in patients treated with radium-223 compared with placebo ( P < 0.001). In a phase III study (ALSYMPCA), mCRPC patients with bone metastases received best standard-of-care treatment with placebo or 223RaCl 2. ![]() Radium-223 is an α-emitting alkaline earth metal ion, which, similar to calcium ions, accumulates in the bone. Food and Drug Administration (FDA) approved radium-223 chloride ( 223RaCl 2) for the treatment of mCRPC patients whose metastases are limited to the bones. The treatment scope for patients with metastatic castrate-resistant prostate cancer (mCRPC) is rapidly expanding. Apple says that every new Mac will be able to run AAA games “with ease”. GamingĮxpect gaming on the Mac to truly take off (well Apple does anyway). Read: How to play soothing white noise in macOS Ventura. You can play soothing white noise on your Mac in Ventura, including the sound of rain, the ocean, or a stream. We also discuss Mac preferences that have a new location in Ventura’s System Settings, including Storage, Hot Corners, Extensions, Mission Control, Appearance, Time Machine and Warranty Information. Read about how Apple has revamped System Preferences in macOS Ventura in our in-depth article. A name that iOS users will likely feel at home with. System Settings is the new name for System Preferences. Read about the new features in Reminders here: Reminders in macOS Ventura. You’ll be able to see your reminders grouped by time and date, you will be able to pin a list and save lists to be used as templates. In macOS Ventura, Apple has added several new features to make Reminders more helpful. Problem with Home directories not being saved to an external storage device.Auto Unlock your Mac with Apple Watch may not work. ![]() Several users claimed that Universal Control between a Mac and iPad no longer works, and that Handoff is unresponsive as well. Universal Control and Handoff broken for some users in macOS 13.3. ![]()
You can drag any bubble to the centre of the browser below the search/URL bar to make it a bookmark bubble, which will appear whenever you open a new tab. The right hand side serves as a collection of open tabs and is basically a collection of bubbles, each representing the site you have opened. Click on a bubble to open the site it represents in a more traditional “browsing rectangle.” Or enter the URL in the address bar, and you will see the site you are headed to appear as a bubble on the right-hand side of the browser. There is also a transparent box that serves as both a search and an address bar. The launch screen of the browser is totally transparent, so you get to see the wallpaper on your desktop (though not the apps on it, thankfully) and a bunch of colourful bubbles representing the sites that the browser recommends. For unlike other worthies which promptly present you with a white box and an address bar, Opera Neon gives you… well, bubbles. So you can imagine how pleasantly surprised we were to see the folks at Opera (those who gave us tabbed browsing, remember), suddenly dip into their design reservoirs and come out with what they termed a “concept browser” because praise be, it looks like no other browser out there.Īnd this hits you from the moment it launches. Which while not bad in itself, can make browsers a trifle dull and predictable. A classic case of substance triumphing over style, as it were. ![]() Changes are found mainly in terms of features and functionality, rather than appearance. In fact, browser design has tended to be a bit on the stagnant side of late, with the predictable box like interface, space for tabs and so on. For, no matter how long the changelogs and how numerous the bug quashes, the stark fact remains that modern day browsers on computers look rather like their mums and dads from a few years ago (a few years is enough for a few generations to mature in tech!). ![]() The times they might be a-changin’, but when it comes to browsers on computers, you might be forgiven for thinking that it’s yesterday once more.
OS X 10.5 included Stacks, a grouping feature that displays files in a "fan" or "grid" style in folders on the Dock an updated Finder that incorporates the Cover Flow visual navigation interface first seen in iTunes, iPhone and iPod touch Quick Look, which allows a "preview" of items by hitting the space bar Spaces, a way to group application windows on more than one virtual desktop Time Machine, an automatic backup utility that allows users to restore deleted files and Boot Camp, Apple's software client to run Microsoft Windows natively on a Mac. Leopard IDG / AppleĪpple introduced OS X Leopard at WWDC 2006, and it became a redefining moment for its software, since it was noted to be the "largest update of OS X." It featured a modernized look with a three-dimensional, reflective Dock, a semitransparent menu bar, larger drop shadows for active windows and new high-resolution icons. OS X Tiger became the first OS to support the Apple-Intel architecture after Apple's transition to Intel x86 processors, and it became the longest running version of Mac OS X prior to Leopard's release 30 months later. OS X 10.4 also introduced Automator, an application that automated tasks and workflows such as renaming large groups of files or resizing dozens of images and VoiceOver, an accessibility interface that provided magnification options, keyboard control and spoken English descriptions of what’s happening on screen. Safari included RSS features and iChat supported up to four participants in a video conference or 10 participants in an audio conference. Dashboard featured widgets for weather, flight information, stock tickers and more. ![]() It included a universal search client, Spotlight, which allowed users to search their entire system from the menu bar for files, emails, contacts, images, calendars and applications. OS X 10.3 also introduced FileVault to encrypt hard drive data with 128-bit keys Font Book, Apple’s simplified application for managing system fonts Xcode, Apple’s developer tool to build Mac applications and a revamped Finder with sidebar for easy access to disk drives, networks and folders. iChat AV let users communicate with audio and video as well as text, and Safari became the Mac’s default web browser after it dropped support for Internet Explorer for Mac. It included Exposé, a useful feature that let users instantly view all open windows at once, view windows of a current program or just view files on the desktop. Panther IDG / AppleĪpple announced OS X Panther at WWDC 2003. Along with a new Finder offering refined search, OS X 10.2 included universal access for the first time and allowed users to magnify screen contents or launch applications with speech dictation. iChat became Apple’s default instant messaging app, with built-in compatibility with AOL Instant Messenger. Announced at the 2002 Macworld Expo, it featured an updated Mail app that placed spam in a junk folder. While earlier versions of OS X did have jungle cat names, they were not used for marketing purposes until OS X Jaguar. iTunes was bundled with OS X 10.1 with CD burning capabilities, DVD playback and support for third-party digital cameras and MP3 players. It provided faster menu navigation and log-in as well as configurable options, such as a movable Dock and new system menus with controls for volume, battery life and AirPort access on the menu bar. OS X Puma was announced at the 2001 Macworld Expo in New York. New apps were included as well, such as Mail, Address Book and TextEdit. OS X Cheetah also debuted the dock that still gives modern Macs their notable appearance. ![]() Announced at the 2000 Macworld Expo in San Francisco, Mac OS X 10.0 introduced the new Aqua User Interface, which showcased title bars with a brushed metal look, brightly colored buttons on windows and photo-realistic icons. ![]() There's also a peek at the upcoming macOS "Monterey." Cheetah IDG / AppleĪpple's first major OS X release, known as Cheetah, was a radical change from the previous Mac OS 9, Apple's Classic Operating System. Here's a look at the progression of OS X from its debut in 2001 to the current version of macOS released in 2020. |